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COVID-19 is the disease caused by a new coronavirus called SARS-CoV-2. WHO first learned of this new virus on 31 December 2019, following a report of a cluster of cases of ‘viral pneumonia’ in Wuhan, People’s Republic of China.
Among those who develop symptoms, most (about 80%) recover from the disease without needing hospital treatment. About 15% become seriously ill and require oxygen and 5% become critically ill and need intensive care.
Complications leading to death may include respiratory failure, acute respiratory distress syndrome (ARDS), sepsis and septic shock, thromboembolism, and/or multiorgan failure, including injury of the heart, liver or kidneys.
In rare situations, children can develop a severe inflammatory syndrome a few weeks after infection.
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The world is in the midst of a COVID-19 pandemic. As WHO and partners work together on the response — tracking the pandemic, advising on critical interventions, distributing vital medical supplies to those in need— they are racing to develop and deploy safe and effective vaccines.
Vaccines save millions of lives each year. Vaccines work by training and preparing the body’s natural defences — the immune system— to recognize and fight off the viruses and bacteria they target. After vaccination, if the body is later exposed to those disease-causing germs, the body is immediately ready to destroy them, preventing illness.
As of 18 February 2021, at least seven different vaccines across three platforms have been rolled out in countries. Vulnerable populations in all countries are the highest priority for vaccination.
At the same time, more than 200 additional vaccine candidates are in development, of which more than 60 are in clinical development. COVAX is part of the ACT Accelerator, which WHO launched with partners in 2020. COVAX, the vaccines pillar of ACT Accelerator, convened by CEPI, Gavi and WHO, aims to end the acute phase of the COVID-19 pandemic by:
- speeding up the development of safe and effective vaccines against COVID-19;
- supporting the building of manufacturing capabilities; and
- working with governments and manufacturers to ensure fair and equitable allocation of the vaccines for all countries – the only global initiative to do so.
Vaccines are a critical new tool in the battle against COVID-19 and it is hugely encouraging to see so many vaccines proving successful and going into development. Working as quickly as they can, scientists from across the world are collaborating and innovating to bring us tests, treatments and vaccines that will collectively save lives and end this pandemic.
Safe and effective vaccines will be a gamechanger: but for the foreseeable future we must continue wearing masks, physically distancing and avoiding crowds. Being vaccinated does not mean that we can throw caution to the wind and put ourselves and others at risk, particularly because it is still not clear the degree to which the vaccines can protect not only against disease but also against infection and transmission.
WHO is bringing the world’s scientists and global health professionals together to accelerate the research and development process, and develop new norms and standards to contain the spread of the coronavirus pandemic and help care for those affected.
The R&D Blueprint has been activated to accelerate diagnostics, vaccines and therapeutics for this novel coronavirus.
The solidarity of all countries will be essential to ensure equitable access to COVID-19 health products.
Global research database
WHO is gathering the latest international multilingual scientific findings and knowledge on COVID-19. The global literature cited in the WHO COVID-19 database is updated daily (Monday through Friday) from searches of bibliographic databases, hand searching, and the addition of other expert-referred scientific articles. This database represents a comprehensive multilingual source of current literature on the topic. While it may not be exhaustive, new research is added regularly.
The WHO evidence retrieval sub-group has begun collaboration with key partners to enrich the citations and build a more comprehensive database with inclusion of other content. The database is built by BIREME, the Specialized Center of PAHO/AMRO and part of the Regional Office’s Department of Evidence and Intelligence for Action in Health.
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